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KMID : 0617220030140010135
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Duksung Bulletin Phamaceutical Sciences
2003 Volume.14 No. 1 p.135 ~ p.141
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Sythesis of 5-phenyl-4,5-dihydro-1H-benzazepin-2-one
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권순경/KWON, Soon-Kyoung
박영남/PARK, Young-Nam
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Abstract
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The first of benzodiazepines was chlordiazepoxide, which was marketed as tranquilizer under the trade name Librium. Now benzodiazepine derivatives are prescribed for insomnia and muscle relaxants as well as to treat anxiety. As benzodiazepines used widely, drug abuse becomes a serious social problem because of psychological and physical dependence and overdose deaths. It is necessary to develop the in vitro diagnostic reagents for the detection of small amount of abused drugs in urine. Because accuracy and convenience for point of care testing systems are indispensable, immunological determinations are fit for our requirements, which react with specific drug antigens and are able to detect small amount of drugs in urine. A benzazepinone derivative(4), which will be used as a component of the reagents for detecting benzodiazepine drugs or their metabolite in urine, was synthesized from 5-phenyltetrahydrofuran-2-one(1) as a key intermediate.
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